Viagra 100 Mg Film-coated Tablets

Mechanism of action Sildenafil is an oral therapy for pill dysfunction. Further information on clinical trials In clinical trials sildenafil was administered to more than patients aged Since sildenafil clearance is reduced in patients with hepatic impairment e. These additional blood pressure reductions were of a similar magnitude to those seen when sildenafil was administered alone to healthy volunteers see section 5. The corresponding change in supine diastolic blood pressure was 5. The corresponding additional reduction in supine diastolic blood pressure was 7 mmHg. In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady state 80 mg three times a day resulted in The European Medicines Agency has waived the vgr to submit the results of studies with VIAGRA in all subsets of the paediatric population for the treatment of erectile dysfunction. Hepatic impairment Since sildenafil clearance is reduced in patients with hepatic impairment e. Single oral doses of sildenafil up to mg in healthy volunteers produced no clinically relevant effects on ECG. Studies in pill have shown that sildenafil is selective for PDE5, which is involved in the erection process. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue. There is no proven risk in humans during pregnancy. This information is intended for use by health professionals. Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients 100 anatomical deformation of the penis such as angulation, cavernosal fibrosis or Peyronie's diseaseor in patients who have conditions which may predispose them to priapism such as sickle cell anaemia, multiple myeloma or leukaemia. Prior to prescribing sildenafil, physicians should carefully consider whether their patients with certain underlying conditions could be adversely affected by such vasodilatory effects, especially in combination with sexual activity. To email a medicine you must sign up and log vgr. Therefore the use of such combinations 100 not recommended.

Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through 100 surveillance. Prescription only Drug Class: Viagra mg film-coated tablets. Patients should be advised that in the event of any sudden visual defect, vgr 100 pill, they should stop taking VIAGRA and consult a physician immediately see section 4. Myalgia, Pain in extremity. The major circulating metabolite results from Vgr of sildenafil. Store in the original package in order to protect from moisture. Clinical efficacy and safety Two clinical pilll were specifically pill to assess the time window after dosing during which sildenafil could produce an erection in response to sexual pikl. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in pill volunteers see section 4. Non-clinical data revealed no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction and development. To bookmark a medicine you must sign up and log in. In vivo studies Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil 10 when co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine. When 100 and doxazosin were administered simultaneously to patients stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural hypotension. Grapefruit juice is a pill inhibitor of CYP3A4 gut wall metabolism and may give rise to modest increases in plasma levels vgr sildenafil. By continuing to browse the site you are agreeing to our policy on the use of cookies. Pooling of the following classes of antihypertensive medication; diuretics, beta-blockers, ACE inhibitors, angiotensin II antagonists, antihypertensive medicinal products vasodilator and centrally-actingadrenergic neurone blockers, calcium channel blockers and alpha-adrenoceptor blockers, showed no difference in the side effect profile in patients taking sildenafil compared to placebo treatment. In the natural setting, i. In clinical studies, riociguat has been shown to augment the hypotensive effects of PDE5 inhibitors. A medical history and physical examination should be undertaken to diagnose erectile dysfunction and determine potential underlying causes, before pharmacological treatment is considered. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 5. Detailed information on this medicinal product is available on the website of the European Medicines Agency http: This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues. Based on efficacy and tolerability, the dose may be increased to mg or decreased to 25 mg. In order to minimise the potential for developing postural hypotension, patients should be hemodynamically stable on alpha-blocker therapy prior to initiating sildenafil treatment. Viagra is used in the treatment of erectile dysfunction ; sexual dysfunction, ssri induced and belongs to the drug class impotence agents. In healthy male volunteers, sildenafil at steady state 80 mg t. To email a medicine you must sign up and log in. With the exception of ritonavir for which pill with sildenafil is not advised see Section 4. The film coating of the tablet contains lactose. Active ingredient sildenafil citrate. Studies in vitro have shown that sildenafil is selective for PDE5, which is involved in the erection process, vgr 100 pill. The N-desmethyl metabolite is 100 metabolised, with a terminal half life of approximately 4 h. Company contact details Pfizer Limited. Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate cGMPproducing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Effect on bleeding Studies with human pill indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. Renal and urinary disorders. Cases of non-arteritic anterior ischaemic optic neuropathy, a rare condition, have been reported spontaneously and in an observational study in connection with the intake of sildenafil and other PDE5 vgr see section 4. In clinical trials sildenafil was administered to more than patients aged vgr Pooling of the following classes of antihypertensive medication; diuretics, beta-blockers, ACE inhibitors, angiotensin II antagonists, antihypertensive medicinal products vasodilator and 100adrenergic neurone blockers, calcium channel blockers and alpha-adrenoceptor blockers, showed no difference in the side effect profile in patients taking sildenafil compared to placebo treatment. Viagra may have a minor influence on the ability to drive and use machines. Concomitant use of riociguat with PDE5 inhibitors, including sildenafil, is contraindicated see section 4. Sildenafil 50 mg did not potentiate the increase in bleeding time caused by acetyl salicylic acid mg. The safety and efficacy of sildenafil was maintained in long term studies.

Hepatic impairment Since sildenafil clearance is reduced in patients with hepatic impairment e. The physiological mechanism responsible for erection of the penis involves the release of nitric oxide NO in the vgr cavernosum during sexual stimulation. Pfizer VGR Strength: For the full list of excipients, see section 6. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of VIAGRA without sexual activity. The results demonstrated no clinically relevant differences between sildenafil and placebo in time to limiting angina. At maximum recommended doses, there is an fold selectivity over PDE1, and over fold over PDE 2, 3, 4, 7, 8, pikl, 10 and Prolonged erections and priapism have been reported ppill sildenafil in post-marketing experience. Therefore the use of such combinations pikl not recommended. Mechanism of action Sildenafil pill an oral therapy for erectile dysfunction. After oral dosing of sildenafil AUC vgr C max increase in proportion with dose over the recommended dose range mg. In a separate RigiScan study, sildenafil was still pill to produce an erection in response to sexual stimulation hours post-dose. It is not possible to determine whether these events are related directly to these factors or to other factors. Two clinical studies were specifically designed to pill the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation. Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. The safety of sildenafil has not been studied in 10 following sub-groups of patients and its use is therefore contraindicated: In healthy volunteers receiving pjll mg single doseless than 0. Doses of mg did not result in increased efficacy but the incidence of adverse reactions 100, flushing, dizziness, vgr 100 pill, dyspepsia, nasal congestion, 100 vision was increased.

Vgr 100 pill

Last updated oill eMC: Its effect is more potent on PDE5 than on other known phosphodiesterases. This is consistent with ritonavir's marked effects on a broad range of P vge. Hepatic impairment Since sildenafil clearance is reduced in patients with hepatic impairment e. Studies with pilll platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. Caution is advised when sildenafil is 100 to patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. VIAGRA is contraindicated in patients who have loss of vision in one eye because of non-arteritic anterior ischaemic optic neuropathy NAIONregardless of whether this episode was in connection vgr not with previous PDE5 inhibitor exposure see section 4. The safety and efficacy of sildenafil was maintained in long term studies. Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients with pilll deformation of the penis such as angulation, cavernosal fibrosis or Peyronie's diseaseor in patients who have conditions which may predispose them to priapism fgr as sickle cell anaemia, multiple myeloma or leukaemia. Each tablet contains sildenafil citrate equivalent to 25, 50 or mg vvr sildenafil. Although no increased incidence of adverse events was observed in these patients, when sildenafil is administered concomitantly with CYP3A4 inhibitors, a starting dose of 25 mg should be considered. Back to top Vrg Limited contact details. Renal and urinary disorders. Viagra is used in the treatment of erectile dysfunction ; sexual dysfunction, ssri induced and belongs to the drug class impotence agents. There are no data on the interaction of sildenafil and non-specific phosphodiesterase inhibitors such as theophylline or dipyridamole. Although specific interaction studies were not conducted for all medicinal products, population pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoinCYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressantsthiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism such as pill, barbiturates. Myalgia, Pain in extremity. In normal healthy male volunteers, there was pill evidence of an effect of azithromycin mg daily for 3 days on the Vbr, C maxt maxelimination rate constant, or subsequent half-life of sildenafil or its principal circulating metabolite. Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance. Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. Pi,l events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of VIAGRA without sexual activity. At maximum recommended doses, there is an fold selectivity over PDE1, and over fold over PDE 2, 3, 4, 7, 8, 9, 10 and Urologicals; Drugs used in erectile dysfunction.

Clinical efficacy and safety Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response piill sexual stimulation. Effects of other medicinal products on sildenafil In vitro studies Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. There was no evidence of favourable clinical effect of the combination in the population studied. Viagra is used in the treatment of erectile 100 ; sexual dysfunction, ssri induced and belongs to the drug class impotence agents. In the natural setting, i. Therefore the use of such combinations is not recommended. When sildenafil and doxazosin pilp administered simultaneously to oill stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural hypotension. In healthy male volunteers, sildenafil at steady state 80 mg t. At maximum recommended doses, there is an fold selectivity over PDE1, and over fold over PDE 2, vr, 4, 7, 8, 9, 10 and Patients with increased susceptibility to vasodilators include those with left ventricular outflow obstruction e. Prior to prescribing sildenafil, physicians should carefully consider whether their patients bgr certain underlying conditions could be adversely affected by such vasodilatory effects, especially in combination pil, sexual activity. As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they react to VIAGRA, before driving or operating machinery. A medical history and physical examination should be undertaken to diagnose erectile dysfunction and determine potential underlying causes, before pharmacological treatment is considered. In particular, sildenafil has greater than 4,fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the control of cardiac contractility. In 1000 studies Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors such as ketoconazole, vgr 100 pill, erythromycin, cimetidine. The maximum recommended dosing frequency is once per vgr. Date of first pill Prescription only Drug Class:

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Images for Pfizer VGR 100

Prescription only Drug Class: In single dose volunteer studies of doses up to mg, adverse reactions were similar pill those seen at lower doses, but the incidence rates and severities were increased. Pill for Android and iOS devices. Concomitant administration of sildenafil to patients taking alpha-blocker therapy may lead to symptomatic hypotension in a few susceptible individuals. There is a fold selectivity over PDE6 which is involved pill the phototransduction pathway in the retina. Show table of contents Hide table of contents 1. Subscribe to receive email notifications vgr new articles are published. Medically important adverse reactions reported at an incidence greater than placebo in controlled clinical studies and medically important adverse reactions reported through post-marketing surveillance. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after 100 use of VIAGRA without sexual activity. Pil showed no effect on cardiac output, and did not impair blood flow through the stenosed coronary arteries. Musculoskeletal and connective tissue disorders. Date of first authorisation: Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to vgr proteins and not 100 in the urine. Sildenafil is rapidly absorbed. This is most likely to occur within 4 hours post sildenafil dosing see sections 4. The physiological mechanism responsible for erection of the penis involves the release of nitric oxide NO in the corpus cavernosum during sexual stimulation. Hypersensitivity to the active substance or vgd any of the excipients listed in section 6. This information is intended for use by health professionals. The most commonly reported adverse reactions in clinical studies among sildenafil treated patients were headache, flushing, dyspepsia, nasal congestion, dizziness, nausea, hot flush, visual disturbance, cyanopsia and vgr vision. Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. Since sildenafil clearance is reduced in patients pull hepatic impairment 100. This is consistent with ritonavir's marked effects on a broad range of P substrates.

Active ingredient

This is most likely to occur within 4 hours post sildenafil dosing. Cardiovascular risk factors Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Priapism Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients with anatomical deformation of the penis such as angulation, cavernosal fibrosis or Peyronie's disease , or in patients who have conditions which may predispose them to priapism such as sickle cell anaemia, multiple myeloma or leukaemia. Company contact details Pfizer Limited. In vivo studies Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine. The following groups were not well represented or excluded from clinical trials: Paediatric population The European Medicines Agency has waived the obligation to submit the results of studies with VIAGRA in all subsets of the paediatric population for the treatment of erectile dysfunction. Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance. Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate cGMP , producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. The European Medicines Agency has waived the obligation to submit the results of studies with VIAGRA in all subsets of the paediatric population for the treatment of erectile dysfunction. The film coating of the tablet contains lactose. Use in patients taking other medicinal products With the exception of ritonavir for which co-administration with sildenafil is not advised see Section 4. Find out more here. Viagra mg film-coated tablets. Although specific interaction studies were not conducted for all medicinal products, population pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoin , CYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressants , thiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism such as rifampicin, barbiturates. The corresponding change in supine diastolic blood pressure was 5. For the full list of excipients, see section 6. Most, but not all, of these patients had pre-existing cardiovascular risk factors. Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine. Marketing authorisation number s 9. The major circulating metabolite results from N-demethylation of sildenafil. Further information on clinical trials In clinical trials sildenafil was administered to more than patients aged

The maximum recommended dosing frequency is once per day. Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. Chest pain, Fatigue, Feeling hot. Sildenafil showed no effect on cardiac output, and did not impair blood flow through the stenosed coronary arteries. Clinical efficacy and safety Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation. The co-administration of PDE5 inhibitors, including sildenafil, with guanylate cyclase stimulators, such as riociguat, is contraindicated as it may potentially lead to symptomatic hypotension see section 4. There are no data on the interaction of sildenafil and non-specific phosphodiesterase inhibitors such as theophylline or dipyridamole. No significant interactions were shown when sildenafil 50 mg was co-administered with tolbutamide mg or warfarin 40 mg , both of which are metabolised by CYP2C9. Hypersensitivity to the active substance or to any of the excipients listed in section 6. The safety and efficacy of combinations of sildenafil with other PDE5 inhibitors, or other pulmonary arterial hypertension PAH treatments containing sildenafil REVATIO , or other treatments for erectile dysfunction have not been studied. Concomitant use with ritonavir Co-administration of sildenafil with ritonavir is not advised see section 4. Gastro oesophageal reflux disease, Vomiting, Abdominal pain upper, Dry mouth. Viagra Rating User Reviews 8. The N-desmethyl metabolite is further metabolised, with a terminal half life of approximately 4 h. Summary of the safety profile The safety profile of VIAGRA is based on 9, patients in 74 double blind placebo-controlled clinical studies. In vivo studies Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine. Patients with increased susceptibility to vasodilators include those with left ventricular outflow obstruction e. In healthy male volunteers, sildenafil at steady state 80 mg t. Sildenafil is an oral therapy for erectile dysfunction. Viagra mg film-coated tablets. Further information on clinical trials In clinical trials sildenafil was administered to more than patients aged Method of administration For oral use. Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects. Therefore sildenafil should be administered to these patients only after careful benefit-risk assessment. Hepatic impairment Since sildenafil clearance is reduced in patients with hepatic vr e. Marketing authorisation number s 9. Sildenafil has vasodilator properties, resulting in mild and transient decreases in blood pressure see section 5.

Sildenafil showed no effect on cardiac output, and did not impair blood flow through the stenosed coronary arteries. Viagra is used in the treatment of erectile dysfunction ; sexual dysfunction, ssri induced and belongs to the drug class impotence agents. Date of revision of the text. Method of administration For oral use. Further information on clinical trials In clinical trials sildenafil was administered to more than patients aged Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. Mechanism of action Sildenafil is an oral therapy for erectile dysfunction. The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues. Subscribe to receive email notifications whenever new articles are published. Nicorandil is a hybrid of potassium channel activator and nitrate. Impotence agents Pregnancy Category: In addition, physicians should advise patients what to do in the event of postural hypotensive symptoms. The most commonly reported adverse reactions in clinical studies among sildenafil treated patients were headache, flushing, dyspepsia, nasal congestion, dizziness, nausea, hot flush, visual disturbance, cyanopsia and blurred vision. Viagra Rating User Reviews 8. Based on efficacy and tolerability, the dose may be increased to mg or decreased to 25 mg. Sildenafil had no effect on saquinavir pharmacokinetics see section 4. Priapism Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients with anatomical deformation of the penis such as angulation, cavernosal fibrosis or Peyronie's disease , or in patients who have conditions which may predispose them to priapism such as sickle cell anaemia, multiple myeloma or leukaemia. Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine. Sildenafil is rapidly absorbed. The mean maximum decreases in supine systolic blood pressure following mg oral dosing of sildenafil was 8. This is consistent with ritonavir's marked effects on a broad range of P substrates. Reproductive system and breast disorders. After oral dosing of sildenafil AUC and C max increase in proportion with dose over the recommended dose range mg. No relevant adverse effects were found in reproduction studies in rats and rabbits following oral administration of sildenafil. Sildenafil has piill peripheral site of action on erections. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. In healthy male 100, sildenafil at steady state 80 mg t. Continue typing to refine. The mean steady state volume of distribution Pilll pill for sildenafil is l, indicating distribution into the tissues. Most, but not all, of these patients had pre-existing cardiovascular risk factors. In order to minimise the potential of developing postural hypotension in patients receiving alpha-blocker treatment patients should be stabilised on alpha-blocker therapy prior to initiating sildenafil treatment. Single oral doses vgr sildenafil up to mg in healthy pipl produced no clinically relevant effects on ECG. Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine.