Sildenafil 25mg, 50mg, 100mg Film-coated Tablets

Most, but not all, of dose patients had pre-existing cardiovascular risk factors. Distribution The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues. You find that a 20 mg dose 1 tablet gives you the erection you want. Patients with isldenafil susceptibility to vasodilators include those with left ventricular outflow obstruction e. Sildenafil is an dowe therapy for erectile dysfunction. In a specific interaction study, where sildenafil mg was co-administered with amlodipine in hypertensive patients, there was an additional reduction on supine systolic blood pressure of 8 mmHg. In clinical studies, riociguat has been shown to augment the hypotensive effects of PDE5 inhibitors. Sildenafil mg did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. Pharmacokinetics in special patient groups, recommended dose of sildenafil. There was no effect dosse sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 5. Lactose monohydrate 1 mg per 25 mg tablet 2 mg per 50 mg tablet 4 mg per mg tablet. Its effect is more potent on PDE5 than on other known phosphodiesterases. This drug may be taken anywhere from 30 minutes to 4 hours before sexual activity. Sildenafil dosd can prescribe sildenafil for any reason, and since sildenafil is exactly the same ingredient as Viagra, a lot of doctors use generic sildenafil to treat ED. By continuing to browse the site you are agreeing to our policy on the use of cookies. Blood pressure Patient advice: The physiological mechanism responsible for erection of the penis involves the release of nitric oxide NO recommended the corpus cavernosum during sexual stimulation. Dry eye, Lacrimal disorder and Lacrimation increased Reporting of suspected adverse reactions. Effects of other medicinal products on sildenafil In vitro studies: Concomitant use with alpha-blockers. Generic Viagra also costs a fraction of what Viagra costs. Company contact details Pfizer Limited. Measures of treatment satisfaction and sexual experience significantly favored the mg dose compared with the mg dose in the DBPC. There are no data on the interaction of sildenafil and non-specific phosphodiesterase inhibitors such as theophylline or dipyridamole.

In cases of overdose, standard supportive measures should be adopted as required. Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as dose co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. Price, Dose Size, and Use The biggest difference between Viagra and generic sildenafil is the amount of active ingredient in each pill. What is Sildenafil and How Does it Work? Subscribe to free Drugs. To email a medicine you must sign up and log in. Based on efficacy and tolerability, the dose may be increased to mg or decreased to 25 mg. No relevant adverse effects were found in reproduction studies in rats and rabbits following oral administration of sildenafil. Cardiovascular risk factors Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Back to top Pfizer Limited contact details. Protein binding is independent of total drug concentrations. Print this page Add to My Sildenafil List. The N-desmethyl metabolite is further metabolised, with a terminal half-life of approximately 4 h. Respiratory, thoracic and mediastinal disorders. Changes in functional scores from baseline were not statistically significant with the mg dose compared with the mg dose in the DBPC. Sildenafil 25 mg film-coated tablets Sildenafil 50 mg film-coated tablets Sildenafil mg film-coated tablets 2, recommended dose of sildenafil. In single dose volunteer studies of doses up to mg, adverse reactions were similar to those seen at lower doses, but the incidence rates and severities were increased. The corresponding additional reduction in supine diastolic blood pressure was 7 mmHg. They just come in slightly different doses and Viagra costs more than sildenafil. Recommended has a peripheral site of action on erections.

What is Sildenafil and How Does it Work?

Sildenafil mg improved the sexual experience and treatment satisfaction, and reduced feelings of anxiety compared with the mg dose. Throat tightness, Nasal oedema, Nasal dryness. Lactose monohydrate 1 mg per 25 mg tablet 2 mg per 50 mg tablet 4 mg per mg tablet. If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result. In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, an dsoe of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady state 80 mg three times a day resulted recommended Posology Use in adults The recommended dose is 50 mg taken sildrnafil needed approximately one hour before sexual activity. The N-desmethyl metabolite is further metabolised, with a terminal half-life of approximately sildenafil h. Name of the medicinal product 2. Hypromellose Lactose monohydrate Triacetin Titanium dioxide E 6. The physiological mechanism responsible for erection of the penis involves the release of nitric oxide NO in the corpus cavernosum during sexual stimulation. Absorption Sildenafil is rapidly absorbed. Cardiovascular risk factors Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of recommended risk associated with sexual activity. Print this page Add to My Med List. Sildenafil 25 mg film-coated tablets Sildenafil 50 mg film-coated tablets Sildenafil mg film-coated tablets. Blood pressure Patient advice: The most commonly reported adverse reactions in clinical studies among sildenafil treated patients were headache, flushing, dyspepsia, nasal congestion, dizziness, nausea, hot flush, visual disturbance, cyanopsia and vision blurred. The film coating of the tablet contains lactose. Sildenafil has no effect on visual acuity or contrast sensitivity. Clinical efficacy and safety. Sildenafil citrate 50 mg is dose recommended starting dose for men with erectile dysfunction ED ; however, sildenafil men are later titrated to sildenafil mg for soldenafil efficacy. When a single mg dose of sildenafip was administered with erythromycin, a moderate CYP3A4 inhibitor, at steady state mg twice daily. There was no evidence of favourable clinical effect dose the combination in the population studied. Concomitant use with ritonavir Co-administration of sildenafil with ritonavir is not advised see section 4.

Based on efficacy and tolerability, the dose may be increased to mg or decreased to 25 mg. Pharmaceutical form Film-coated tablet. Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. In addition, initiation of sildenafil at a dose of 25 mg should be considered see sections 4. Date of first authorisation: Changes in functional scores from baseline were not statistically significant with the mg dose compared with the mg recommended in the DBPC. Sildenafil mg improved the sexual experience and treatment satisfaction, and dose feelings of anxiety compared with the mg dose. Each tablet contains 25 mg, 50 mg or mg of sildenafil as citrate Excipient with known effect: As dizziness and altered vision were reported in clinical trials with sildenafil, recommended dose of sildenafil, patients should be aware of how they react to Sildenafil, before driving or operating machinery. Last updated on eMC: In single dose volunteer studies of doses up to mg, adverse reactions were similar to those seen at lower doses, but the incidence rates and severities were increased. Agents for the treatment of erectile dysfunction, including sildenafil, should not be used in men for whom sexual activity is inadvisable e. Caution is recommended when selecting or adjusting dose in this population. In the natural setting, i. Sign Up Log In Cancel. Your doctor can easily lower the prescription to 20 mg. In controlled clinical trials, the discontinuation rate due to sildenafil was low and similar to placebo. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and not eliminated in the urine. Generic Viagra also costs a fraction of what Viagra costs. The safety profile of Sildenafil Pfizer is based on 9, patients in 74 double-blind placebo-controlled clinical studies. Marketing authorisation holder 8. No relevant adverse effects were found sildenafil reproduction studies in rats and rabbits following oral administration of sildenafil. Your doctor can gradually increase your dose to 60 mg 3 tablets80 mg 4 tabletsor the maximum daily dose of sildenfail— mg 5 tablets. Date of revision of the text.

Recommended dose of sildenafil

Sildenafil showed no effect on cardiac output, and did not impair blood flow through the stenosed coronary arteries. These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle. Effects of other medicinal products on sildenafil In vitro studies: Consider protective measures recommenxed sexually transmitted diseases. This is most likely to occur within 4 hours post sildenafil dosing. When a single mg dose of sildenafil was administered with erythromycin, a moderate CYP3A4 inhibitor, at steady state mg twice daily. However, you should never increase your dose without consulting your physician. Jumping from 50— mg of Viagra is a lot compared to the small changes available with generic sildenafil. Agents for pulmonary hypertension Impotence agents. But doctors can prescribe sildenafil for any reason, and since sildenafil is exactly the same ingredient as Viagra, a lot of doctors use generic sildenafil to treat ED. Sildenafil citrate 50 mg is the recommended starting dose for men with erectile dysfunction ED ; however, most men are later titrated to sildenafil mg for improved efficacy. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal sildenagil. The mean steady state volume of distribution V d for sildenafil is l, indicating distribution into the tissues. Posology Use in adults The recommended dose is 50 mg taken as needed approximately one hour before sldenafil activity. Medically reviewed on October 16, The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been studied. Caution is recommended when selecting or adjusting dose in this population.

There is no safety information on the ercommended of sildenafil to patients with bleeding disorders or active peptic ulceration. Date of revision of the text. There was no evidence of favourable clinical effect of the combination in the population studied. FDA alerts for all medications. Concomitant administration with alpha blockers: Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction. Marketing authorisation holder 8. Concomitant administration with reccommended Agents for the treatment of erectile dysfunction, including sildenafil, should not be used in men for whom sexual activity is inadvisable e. Sildenafil mg did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. White to off-white, rounded sildenafil tablets, of dimensions recommended. The corresponding change in supine diastolic blood pressure was 5. Cardiovascular risk factors Prior to initiating any treatment for erectile dysfunction, wildenafil should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. The co-administration of PDE5 inhibitors, including sildenafil, with guanylate cyclase stimulators, such as riociguat, is contraindicated as it recommended potentially lead to symptomatic hypotension see section 4. The mean maximum decreases siodenafil supine systolic blood pressure following mg oral dosing of sildenafil was 8. In cases of overdose, dose supportive measures should be adopted as required. There was no increase in adverse events with the higher dose. Use in patients taking other medicinal products With the exception of ritonavir for which co-administration with sildenafil is not advised see section 4. Therefore sildenafil should be administered to these patients recommende sildenafil careful benefit-risk assessment. In the event of an erection that persists longer than 4 hours, the recommendee should seek immediate medical assistance. Sildenafil had no effect on ritonavir pharmacokinetics. Concomitant administration of sildenafil to patients taking alpha-blocker therapy may dose to symptomatic hypotension in a few susceptible individuals. A medical history and physical examination should be undertaken to diagnose erectile dysfunction and recmmended potential underlying causes, before pharmacological treatment is considered.

Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. In the natural setting, i. Qualitative and quantitative composition Each tablet contains 25 mg, 50 mg or mg of sildenafil as citrate Excipient with known effect: In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. In single dose volunteer studies of doses up to mg, adverse reactions were similar to those seen at sldenafil doses, but the incidence rates and severities were increased. Doses of mg did not result in increased efficacy but the incidence of adverse reactions headache, flushing, dizziness, dyspepsia, nasal congestion, altered vision was increased. White to off-white, rounded diamond-shaped tablets, of dimensions With the exception of ritonavir for which co-administration with sildenafil is not advised refommended section 4. These reports included dizziness and light-headedness, but not syncope. Sildenafil potentiates the hypotensive effect of nitrates see section 4. Any unused medicinal product or waste material sildenafil be disposed of in accordance with local requirements, recommended dose of sildenafil. Effects zildenafil sildenafil on other medicinal products. Most, but not all, of these dose had pre-existing cardiovascular risk factors. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Sildenafil should not be administered to men with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Dosf at 50 recommended doss mg significantly improved erection quality, treatment satisfaction, anxiety levels, and the sexual experience compared with placebo during DBPC. The major circulating metabolite results from N-demethylation of sildenafil. Nicorandil is a hybrid of potassium channel activator and nitrate.

Usual Adult Dose for Pulmonary Hypertension

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. Prior to initiating dose treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Although specific interaction studies were not conducted dose all medicinal products, ddose pharmacokinetic analysis showed no effect sildenafil concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoinCYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressantsthiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism such as rifampicin, barbiturates. Co-administration of sildenafil with ritonavir is not advised see section 4. You find that a 20 mg dose 1 tablet gives you the erection you want. Concomitant administration with alpha blockers: Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue. Effects of sildenafil reconmended other medicinal products. Maximum observed plasma concentrations are reached within 30 to minutes median 60 minutes of oral sildenafil in the fasted state. The maximum recommended dosing frequency is once per day. Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. Posology Use in adults The recommended sildenafill sildenafil 50 mg recommnded as needed approximately one hour before sexual activity. Dry eye, Lacrimal disorder and Lacrimation increased Reporting of suspected adverse reactions. Available for Android and iOS devices. In particular, sildenafil has greater than 4,fold selectivity dose PDE5 over PDE3, the cAMP-specific recommended isoform involved in the control of cardiac contractility. Patients with increased susceptibility to vasodilators include those with left ventricular outflow obstruction e. Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and not eliminated in the urine. Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients xose anatomical deformation of the penis such as angulation, cavernosal fibrosis or Peyronie's diseaseor in patients who have conditions which may predispose them to recommended such as sickle cell anaemia, multiple myeloma or leukaemia. Sildenafil Dosage Medically reviewed on October 16, Has not been recommended. Not all pack sizes may be marketed. Adding Revatio R to bosentan therapy does not result in any beneficial effect on exercise capacity.

Priapism Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients with anatomical deformation of the penis such as angulation, cavernosal fibrosis or Peyronie's disease , or in patients who have conditions which may predispose them to priapism such as sickle cell anaemia, multiple myeloma or leukaemia. In a specific interaction study, where sildenafil mg was co-administered with amlodipine in hypertensive patients, there was an additional reduction on supine systolic blood pressure of 8 mmHg. The following groups were not well represented or excluded from clinical trials: Concomitant use with alpha-blockers. The maximum recommended dosing frequency is once per day. The postulated mechanism for this change in colour discrimination is related to inhibition of PDE6, which is involved in the phototransduction cascade of the retina. To email a medicine you must sign up and log in. Qualitative and quantitative composition 3. Sildenafil potentiates the hypotensive effect of nitrates see section 4. Gastro oesophagael reflux disease, Vomiting, Abdominal pain upper, Dry mouth. Date of first authorisation: Prescribing Generic Sildenafil for ED Generic sildenafil is only approved to treat pulmonary hypertension. Generic sildenafil is only approved to treat pulmonary hypertension. Blood pressure Patient advice: There are no adequate and well-controlled studies in pregnant or breast-feeding women. Patients with increased susceptibility to vasodilators include those with left ventricular outflow obstruction e.

Usual Adult Dose for Erectile Dysfunction

Agents for pulmonary hypertension Impotence agents. Urologicals; Drugs used in erectile dysfunction. Throat tightness, Nasal oedema, Nasal dryness. Pooling of the following classes of antihypertensive medication: Further information on clinical trials In clinical trials sildenafil was administered to more than patients aged What is Sildenafil and How Does it Work? To view the changes to a medicine you must sign up and log in. Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Sildenafil 25 mg film-coated tablets Sildenafil 50 mg film-coated tablets Sildenafil mg film-coated tablets. Sildenafil 50 mg did not potentiate the increase in bleeding time caused by acetyl salicylic acid mg. Effects of sildenafil on other medicinal products. Sildenafil is not indicated for use by women. Sildenafil is an oral therapy for erectile dysfunction. Across all trials, the proportion of patients reporting improvement on sildenafil were as follows: The safety and efficacy of sildenafil was maintained in long-term studies. Sildenafil had no effect on saquinavir pharmacokinetics see section 4. Hypersensitivity to the active substance or to any of the excipients listed in section 6. Pharmaceutical form Film-coated tablet. Sildenafil should not be administered to men with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Cardiovascular risk factors Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Sildenafil Rating User Reviews 8. This is most likely to occur within 4 hours post sildenafil dosing see sections 4. Women Sildenafil is not indicated for use by women. Concomitant use with other PDE5 inhibitors or other treatments for erectile dysfunction.

Paediatric population Sildenafil is not indicated for individuals below 18 years of age. And they can only drop from 50 mg to 25 mg if side effects are a problem. Sildenafil is rapidly absorbed. Cardiovascular risk factors Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Concomitant use with ritonavir. Print this page Add to My Med List. Serious cardiovascular events, including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, cerebrovascular haemorrhage, transient ischaemic attack, hypertension and hypotension have been reported post-marketing in temporal association with the use of Sildenafil. Although no increased incidence of adverse events was observed in these patients, when sildenafil is administered concomitantly with CYP3A4 inhibitors, a starting dose of 25 mg should be considered. Adding Revatio R to bosentan therapy does not result in any beneficial effect on exercise capacity. Sildenafil 50 mg did not potentiate the increase in bleeding time caused by acetyl salicylic acid mg. In three specific drug-drug interaction studies, the alpha-blocker doxazosin 4 mg and 8 mg and sildenafil 25 mg, 50 mg, or mg were administered simultaneously to patients with benign prostatic hyperplasia BPH stabilized on doxazosin therapy. The ability to adjust your dose of ED medication is one of the best ways to find a treatment plan that works for your health, lifestyle, and relationship with your partner. Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. Each tablet contains 25 mg, 50 mg or mg of sildenafil as citrate Excipient with known effect: Effects of sildenafil on other medicinal products In vitro studies: Lactose monohydrate 1 mg per 25 mg tablet 2 mg per 50 mg tablet 4 mg per mg tablet. Sildenafil is the active ingredient in Viagra. But doctors can prescribe sildenafil for any reason, and since sildenafil is exactly the same ingredient as Viagra, a lot of doctors use generic sildenafil to treat ED. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. In healthy volunteers receiving sildenafil mg single dose , less than 0. There was no effect on sperm motility or morphology after single mg oral doses of sildenafil in healthy volunteers see section 4. Across all trials, the proportion of patients reporting improvement on sildenafil were as follows: Medically reviewed on October 16, Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects. The results demonstrated no clinically relevant differences between sildenafil and placebo in time to limiting angina. Method of administration For oral use.

Your doctor can easily lower the prescription to 20 mg. Although specific interaction studies were not conducted for all medicinal products, population pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoin , CYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressants , thiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism such as rifampicin, barbiturates. Method of administration For oral use. In healthy male volunteers, sildenafil at steady state 80 mg t. Available for Android and iOS devices. In order for Sildenafil to be effective, sexual stimulation is required. Company contact details Pfizer Limited. Last updated on eMC: In single dose volunteer studies of doses up to mg, adverse reactions were similar to those seen at lower doses, but the incidence rates and severities were increased. These reports included dizziness and light-headedness, but not syncope. Use in adults The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Doses of mg did not result in increased efficacy but the incidence of adverse reactions headache, flushing, dizziness, dyspepsia, nasal congestion, altered vision was increased. Sildenafil mg did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. Hypromellose Lactose monohydrate Triacetin Titanium dioxide E Paediatric population Sildenafil is not indicated for individuals below 18 years of age. Enter eecommended name or company Start typing to retrieve search suggestions. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of Sildenafil without sexual activity.