Cefuroxime Axetil

Elimination The serum half-life is between 1 and 1. Reproductive studies in animals have shown no effects on fertility. Treatment related adverse reactions, all grades, are listed below by MedDRA body system organ class, frequency and grade of severity. In patients with markedly impaired renal function it is recommended that the dosage of cefuroxime should be reduced to compensate for its slower excretion. J01DC02 Mechanism of action. Qualitative and quantitative composition 3. Morganella morganii Proteus vulgaris Pseudomonas aeruginosa Serratia marcescens Gram-negative anaerobes: Cefuroxime axetil may be considered as an empirical therapy for a range of community-acquired infections, including those in which beta-lactamase-producing strains of common respiratory pathogens are identified as axetil causative organisms. Optimum absorption occurs when it is administered shortly after a cefuroxime. Important information about excipients Special care should be taken with phenylketonuric patients because of the aspartame containing coating. Interference with diagnostic tests. Shorter courses 5 to 10 days' of cefuroxime axetil were at least as effective as a 10 day course. Hypersensitivity reactions Special care is indicated in patients who have experienced an allergic reaction to penicillins or other beta-lactam antibiotics because there is a risk of cross-sensitivity. After oral administration cefuroxime axetil is absorbed from the gastrointestinal tract and rapidly hydrolysed in the intestinal mucosa and blood to release cefuroxime into the circulation. The prevalence cefuroxime acquired resistance may vary geographically and with time for selected species and local information on resistance is desirable, particularly when treating severe infections. The tablet can be divided into equal doses. Cefuroxime axetil, a prodrug of the cephalosporin cefuroxime, has proven in vitro antibacterial activity against several gram-positive and gram-negative organisms, cefuroxime axetil, including those most axetil associated axetil various common community-acquired infections. Marketing authorisation holder 8. Cefuroxime axetil undergoes hydrolysis by esterase enzymes to the active antibiotic, cefuroxime.

Overgrowth of non-susceptible microorganisms As with other antibiotics, use of cefuroxime axetil may result in the overgrowth of Candida. This diagnosis should cefuroxime considered in patients with diarrhoea during or subsequent to the administration of cefuroxime see section 4, cefuroxime axetil. Description of selected adverse reactions Cephalosporins as a class tend to be absorbed onto the surface of red cells membranes and react with antibodies directed against the drug to produce a positive Coombs' test which can interfere with cefuroxime of blood and very rarely haemolytic anaemia. Overgrowth of non-susceptible microorganisms. In many areas, ESBL detection and characterization is recommended or mandatory for infection control axetil. Find out more here. Concomitant use of probenecid is not recommended. Reporting of suspected adverse reactions. There are limited data from the use of cefuroxime in pregnant women. Indication Dosage Acute tonsillitis and pharyngitis, acute bacterial sinusitis mg twice daily Acute otitis media mg twice daily Acute exacerbations of chronic bronchitis mg twice daily Cystitis mg twice daily Pyelonephritis mg twice daily Uncomplicated skin and soft tissue infections mg twice daily Lyme disease mg twice daily for 14 days range of 10 to 21 days Table 2. Cefuroxime axetil is a broad spectrum antibacterial agent with a pharmacokinetic profile that permits convenient twice-daily administration. Borrelia burgdorferi Microorganisms for which acquired resistance may be a problem Gram-positive aerobes: Cefuroxime is primarily excreted by the kidneys. The possibility of sensitisation should be taken axetil account. Placebo-controlled trial data were not available. Hepatic impairment There are no data available for patients with hepatic impairment. Posology The usual course of therapy is seven days may range from five to ten days. To bookmark a medicine you must sign up and log in. Adverse effects at therapeutic doses are not expected, although a risk of diarrhoea and fungus infection of the mucous membranes cannot be excluded. Consideration should be given to official guidance on the appropriate use of antibacterial agents. To view the changes to a medicine you must sign up and log in. Commonly susceptible species Gram-positive aerobes: Cefuroxime mg coated tablets contain

Jarisch-Herxheimer reaction Xaetil Jarisch-Herxheimer reaction has been seen following cefuroxime axetil treatment of Lyme disease. Axetil No special precaution is necessary in the elderly patients with normal renal function at dosages up to the normal maximum of 1 g per day. Special care is indicated in patients who have experienced an allergic reaction to penicillins or other beta-lactam antibiotics because there is a risk cefuroxume cross-sensitivity. The frequencies assigned to all other undesirable effects i. Reporting of suspected adverse reactions. Cefuroxime is excreted in human milk in small quantities. Overgrowth of non-susceptible microorganisms As with axetil antibiotics, use of cefuroxime axetil may result in the overgrowth of Candida. To view the changes to a medicine you must sign up and log in. Breastfeeding Cefuroxime is excreted in human milk in small quantities. This information is intended for use by health professionals. Skin and subcutaneous tissue disorders. No differences in the cefuroxime of cefuroxime were observed between males and females. Enterococcus faecalis Enterococcus faecium Gram-negative aerobes: Gamma glutamyl axetil activity in rat urine is inhibited by various cephalosporins, however the level of inhibition is less with cefuroxime. Store in the original packaging in order to protect axtil moisture This medicinal product does not require any special temperature storage conditions 6. Sign Up Log In Cancel. The drug is an cefuroxime and well tolerated treatment in patients with various infections, including otitis media, pharyngitis, sinusitis, CAP and acute exacerbations of chronic bronchitis. Morganella morganii Proteus vulgaris Pseudomonas aeruginosa Serratia marcescens Gram-negative anaerobes: Elimination The serum half-life is between 1 and 1. Cefuroxime passes the blood-brain barrier when the meninges are inflamed. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme: Data from large clinical studies were used to determine the cefuroxime of very common to rare undesirable effects. This may have significance in the interference in clinical laboratory tests in humans.

In case of severe hypersensitivity reactions, treatment with cefuroxime must be discontinued immediately and adequate emergency measures must be initiated. Therefore, as with all such antibiotics, in patients with markedly impaired renal function i. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Oral use Cefuroxime axetil tablets should be taken after food for optimum absorption. Important information about excipients Special care should be taken with phenylketonuric patients because of the axetil containing coating. Hepatic impairment There are no data available for patients with hepatic impairment. Borrelia axetil Microorganisms for which acquired resistance may be a cefuroxime Gram-positive aerobes: No differences in the pharmacokinetics of cefuroxime were observed between males and females. Serum levels of cefuroxime can be reduced by haemodialysis and peritoneal dialysis, cefuroxime axetil. Symptoms of overdose can occur if the dose is not reduced appropriately in patients with axetil impairment cefuroxime sections 4. Uncomplicated skin and soft tissue infections. Special care is indicated in patients who have experienced an cefuroxime reaction to penicillins or other beta-lactam antibiotics because there is a risk of cross-sensitivity. In an era of axetil emerging bacterial resistance, empirical cefuroxime with bacterial agents, potentially preventing the emergence of bacterial resistance to agents such as cefuroxime axetil may ensure the appropriate use of newer antibacterial agents, potentially preventing the emergence of bacterial resistance to these newer drugs. Non-clinical data reveal no special hazard for humans based on studies of safety pharmacology, repeated dose toxicity, genotoxicity and toxicity to reproduction and development. Jarisch-Herxheimer reaction The Jarisch-Herxheimer reaction has been seen following cefuroxime axetil treatment of Lyme disease. Children aged two years or older with otitis media or, where appropriate, with more severe infections. No special precaution is necessary in the elderly patients with normal renal function at dosages up to the normal maximum of 1 g per day. Transient rises in serum liver enzymes have been observed which are usually reversible.

Cefuroxime axetil

Prolonged use may also result in the overgrowth of other non-susceptible microorganisms e. Furthermore, sequential therapy with intravenous cefuroxime mg 2 or 3 times daily for 2 to 5 days followed by oral cefuroxime axetil mg twice daily for 3 to 8 days proved an effective treatment cefuroxime adult patients with community-acquired pneumonia CAP. Axetil influenzae Haemophilus parainfluenzae Moraxella catarrhalis. Cefuroxime is excreted in human milk in small quantities. Special care is indicated in patients who have experienced an allergic reaction to penicillins or other beta-lactam antibiotics because there is a risk of cross-sensitivity. As with other antibiotics, use of cefuroxime axetil may result in the overgrowth of Candida. Treatment related adverse reactions, all grades, are listed below by MedDRA body system organ class, frequency and grade of severity. Last updated on eMC: Before beginning treatment, it should be established whether the patient has a history of severe hypersensitivity reactions to cefuroxime, to other cephalosporins or to any other type of beta-lactam agent. Medicinal products that inhibit peristalsis should not axetil given see section 4. Cefuroxime is effectively removed by dialysis. Cefuroxime mg coated tablets contain There is no clinical trial data available on the use of cefuroxime axetil in children under the age of 3 months. Company contact details Sandoz Limited. Reporting suspected adverse reactions after authorisation of the medicinal product is important, cefuroxime axetil. Morganella morganii Proteus vulgaris Pseudomonas aeruginosa Serratia marcescens. Microorganisms for which acquired resistance may be a problem. Cefuroxime of cefuroxime in excess of the minimum inhibitory levels for common pathogens can be achieved in the tonsilla, sinus tissues, bronchial mucosa, bone, pleural fluid, joint fluid, synovial fluid, interstitial fluid, bile, axetil and aqueous humor. In patients with markedly impaired renal function it is recommended that the dosage of cefuroxime should be reduced to compensate for its slower excretion. Special care should be taken with phenylketonuric cefuroxime because of the aspartame containing coating. The pharmacokinetics of cefuroxime is linear over the oral dosage range of to mg.

There are no data on the effects of cefuroxime axetil on fertility in humans. Hypersensitivity to the active substance or to any of the excipients listed in section 6. Cefuroxime axetil undergoes hydrolysis by esterase enzymes to the active antibiotic, cefuroxime. To bookmark a medicine you must sign up and log in. Reproductive studies in animals have shown no effects on fertility. Store axetil the original packaging in cefuroxime to protect cefurozime moisture This medicinal product does not require axettil special temperature storage conditions 6. Concomitant use with oral anticoagulants may give rise to increased INR. Following administration of cefuroxime axetil tablets peak serum levels 2. Continue typing to refine. Cefuroxime axetil is indicated for the treatment of the infections listed below in adults and children from the age of 3 months see sections 4. Breastfeeding Cefuroxime is excreted in human milk in small quantities. Axrtil results directly from the bactericidal activity of cefuroxime axetil on the causative bacteria of Lyme disease, the spirochaete Borrelia burgdorferi, cefuroxime axetil. Excipients axetip known effect: In case of severe hypersensitivity reactions, treatment with cefuroxime must be discontinued immediately and adequate emergency measures must axetil initiated. Absorption After oral axetil cefuroximr axetil is absorbed from the gastrointestinal tract and rapidly hydrolysed in the intestinal mucosa and blood to release cefuroxime into the circulation. There is no clinical trial data available on the use of cefuroxime axetil in children under the age of 3 months. Interference with cefuroxime tests. Morganella morganii Proteus vulgaris Pseudomonas aeruginosa Serratia marcescens Gram-negative anaerobes:

There cefuroxime no clinical trial data available on the use of cefuroxime axetil in children under the age of 3 months. Last updated on eMC: Oral use Cefuroxime axetil tablets should be taken after food for optimum absorption. Streptococcus pneumoniae Gram-negative aerobes: This diagnosis should be considered in patients with diarrhoea during or subsequent to the administration of cefuroxime see section 4. Axetil should be reassured that this is a common and usually self-limiting consequence of cefuroxime treatment of Lyme disease see section 4. Data from large clinical studies were used to determine the axetil of very common to rare undesirable effects, cefuroxime axetil. Furthermore, sequential therapy with intravenous cefuroxime mg 2 or 3 times daily for 2 to 5 days followed by oral cefuroxime axetil mg twice daily for 3 to 8 days proved ceufroxime effective treatment in adult patients with community-acquired pneumonia CAP. Cefuroxime axetil undergoes hydrolysis by esterase enzymes to the active antibiotic, cefuroxime. The majority of adverse events primarily gastrointestinal disturbances were mild to moderate in axetil and reversible upon discontinuation of treatment, with very few serious adverse events reported. In an era of rapidly emerging bacterial resistance, empirical treatment with bacterial agents, potentially preventing the emergence of bacterial resistance to agents such as cefuroxime axetil may cefuroxime the appropriate use of newer antibacterial agents, potentially preventing the emergence of bacterial resistance to these newer drugs. As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of cefuroxime axetil in at least some types of infections is questionable. Optimum absorption occurs when it is administered shortly after a axetil. Some strains that produce beta-lactamases are susceptible or intermediate to 3rd or 4th generation cephalosporins with these breakpoints and should be reported as found, i. In patients with cefuroxime impaired renal function it is recommended that the dosage of cefuroxime should be reduced to compensate for its adetil excretion. Store in the original packaging in order to cefkroxime from moisture. Hypersensitivity to the active substance or to any of the excipients listed in section 6.

Active ingredient

Non-clinical data reveal no special hazard for humans based on studies of safety pharmacology, repeated dose toxicity, genotoxicity and toxicity to reproduction and development. There are no data available for patients with hepatic impairment. To bookmark a medicine you must sign up and log in. Interference with diagnostic tests. Cefuroxime axetil is indicated for the treatment of the infections listed below in adults and children from the age of 3 months see sections 4. Acute tonsillitis and pharyngitis, acute bacterial sinusitis. In numerous randomised, controlled trials, 5 to 10 days' treatment with oral cefuroxime axetil or mg twice daily was an effective treatment in patients with upper URTI and lower respiratory tract infections LRTI as assessed by clinical and bacteriological criteria. Find out more here. Breastfeeding Cefuroxime is excreted in human milk in small quantities. In addition the incidence of adverse reactions associated with cefuroxime axetil may vary according to the indication. Concentrations of cefuroxime in excess of the minimum inhibitory levels for common pathogens can be achieved in the tonsilla, sinus tissues, bronchial mucosa, bone, pleural fluid, joint fluid, synovial fluid, interstitial fluid, bile, sputum and aqueous humor. Reproductive studies in animals have shown no effects on fertility. Some strains that produce beta-lactamases are susceptible or intermediate to 3rd or 4th generation cephalosporins with these breakpoints and should be reported as found, i. No differences in the pharmacokinetics of cefuroxime were observed between males and females. This results in the interruption of cell wall peptidoglycan biosynthesis, which leads to bacterial cell lysis and death. After oral administration cefuroxime axetil is absorbed from the gastrointestinal tract and rapidly hydrolysed in the intestinal mucosa and blood to release cefuroxime into the circulation. Cefuroxime axetil mg coated tablets contain 0. Cefuroxime is excreted in human milk in small quantities. Special care should be taken with phenylketonuric patients because of the aspartame containing coating. Commonly susceptible species Gram-positive aerobes: Overgrowth of non-susceptible microorganisms. Fertility There are no data on the effects of cefuroxime axetil on fertility in humans. The drug is an effective and well tolerated treatment in patients with various infections, including otitis media, pharyngitis, sinusitis, CAP and acute exacerbations of chronic bronchitis. Cefuroxime is excreted by glomerular filtration and tubular secretion.

Adverse effects at therapeutic doses are not expected, although a risk of diarrhoea and fungus infection of the mucous membranes cannot be excluded. Excipients with known effect: Oral use Cefuroxime axetil tablets should be taken after food for optimum absorption. Special patient populations Gender No differences in the pharmacokinetics of cefuroxime were observed between males and females. This diagnosis should be considered in patients with diarrhoea during or subsequent to the administration of cefuroxime see section 4. Concomitant use of probenecid is not recommended. Cefuroxime inhibits bacterial cell wall synthesis following attachment to penicillin binding proteins PBPs. Cefuroxime is usually active against the following microorganisms in vitro. Cefuroxime is excreted in human milk in small quantities. Jarisch-Herxheimer reaction The Jarisch-Herxheimer reaction has been seen following cefuroxime axetil treatment of Lyme disease. However, as this medicine may cause dizziness, patients should be warned to be cautious when driving or operating machinery. Overgrowth of non-susceptible microorganisms. Continue typing to refine. To view the changes to a medicine you must sign up and log in. Store in the original packaging in order to protect from moisture This medicinal product does not require any special temperature storage conditions 6. Coated tablets White to slightly yellowish, biconvex, oblong tablets scored on both sides. Children aged two years or older with otitis media or, where appropriate, with more severe infections. Consideration should be given to official guidance on the appropriate use of antibacterial agents. The frequency categories assigned to the adverse reactions below are estimates, as for most reactions suitable data for example from placebo-controlled studies for calculating incidence were not available. Cefuroxime axetil axetil indicated for the treatment cefuroxime the infections listed below in adults and children from the axetil of 3 months see sections 4. Renal impairment Cefuroxime safety and efficacy of cefuroxime axetil in patients with renal failure have not been established. Cefuroxime is excreted in human milk in small quantities. The safety and efficacy of cefuroxime axetil in patients with renal failure have not been established. This information is intended for use by health professionals. There are no data on the effects of cefuroxime axetil on fertility in humans.

Sign Up Log In Cancel. Excipients with known effect: Children aged two years or older with otitis media or, where appropriate, with more severe infections. Name of the medicinal product 2. Marketing authorisation number s 9. Cefuroxime is excreted by glomerular filtration and tubular secretion. Pharmaceutical form Coated tablets White to slightly yellowish, biconvex, oblong tablets scored on both sides. To email a medicine you must sign up and log in. Enterococcus faecalis Enterococcus faecium Gram-negative aerobes: Reporting of suspected adverse reactions. Overgrowth of non-susceptible microorganisms As with other antibiotics, use of cefuroxime axetil may result in the overgrowth of Candida. In numerous randomised, controlled trials, 5 to 10 days' treatment with oral cefuroxime axetil or mg twice daily was an effective treatment in patients with upper URTI and lower respiratory tract infections LRTI as assessed by clinical and bacteriological criteria. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme: The development of a positive Coomb's Test associated with the use of cefuroxime may interfere with cross matching of blood see section 4. Cefuroxime inhibits bacterial cell wall synthesis following attachment to penicillin binding proteins PBPs. Cefuroxime axetil is indicated for the treatment of the infections listed below in adults and children from the age of 3 months see sections 4. Enter medicine name or company Start typing to retrieve search suggestions. The drug is an effective and well tolerated treatment in patients with various infections, including otitis cefuroxime, pharyngitis, sinusitis, CAP and acute exacerbations of chronic bronchitis. Axetil Dosage Acute tonsillitis and pharyngitis, acute bacterial sinusitis mg twice daily Acute otitis media mg twice daily Acute exacerbations of chronic bronchitis mg twice daily Cystitis mg twice daily Pyelonephritis mg twice daily Uncomplicated skin and soft tissue infections mg twice daily Lyme disease mg twice daily for 14 days range of 10 to 21 days Table 2. Commonly susceptible species Gram-positive aerobes: Cefuroxime inhibits bacterial cell wall synthesis following attachment to penicillin binding proteins PBPs. Enterococcus faecalis Enterococcus faecium, cefuroxime axetil. Cefuroxime axetil undergoes hydrolysis by esterase enzymes to the active antibiotic, cefuroxime. Interference with diagnostic tests The development of a positive Coomb's Test associated with the use ceffuroxime cefuroxime may interfere with cross matching of blood see section 4. Overgrowth of non-susceptible microorganisms. Studies in animals have shown no harmful effects on pregnancy, embryonal or foetal development, cefuroxxime or postnatal development.